Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012436)
Formula Reactant AZD8931 Product AZD8931 M10
Reactant Info Product Info
Metabolic Type Other reaction - Hydroxy-chlorofluorophenylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012434 AZD8931 AZD8931 M11 Oxidation - Monooxygenation AZD8931 [1]
MR012427 AZD8931 AZD8931 M12 Oxidation - O-desmethylation AZD8931 [1]
MR012442 AZD8931 AZD8931 M13 Oxidation - N-desmethylation AZD8931 [1]
MR012439 AZD8931 AZD8931 M14 Conjugation - N-hydroxymethylation AZD8931 [1]
MR012441 AZD8931 AZD8931 M15 Other reaction - Hydroxypiperidine AZD8931 [1]
MR012429 AZD8931 AZD8931 M18 Oxidation - O-despiperidine AZD8931 [1]
MR012443 AZD8931 AZD8931 M20 Unclear - N-acetic acid AZD8931 [1]
MR012432 AZD8931 AZD8931 M9 Oxidation - N-dealkylation AZD8931 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012438 AZD8931 M10 AZD8931 M3,M6,M7 Conjugation - Monooxygenated glucosidation AZD8931 [1]
MR012437 AZD8931 M10 AZD8931 M4 Oxidation - Monooxygenation AZD8931 [1]
References
1 Metabolic disposition of AZD8931, an oral equipotent inhibitor of EGFR, HER2 and HER3 signalling, in rat, dog and man

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