Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012605)
Formula Reactant LMP400 Product LMP400 Metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012604 LMP400 LMP400 Metabolite M1 Oxidation - O-dealkylation LMP400 [1]
MR012601 LMP400 LMP400 Metabolite M3 Oxidation - Demethylenation LMP400 [1]
MR012606 LMP400 LMP400 Metabolite M6 Reduction - Ketone reduction LMP400 [1]
References
1 Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons

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