Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012704)
Formula Reactant PhIP Product PhIP N2-glucuronide metabolite
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012698 PhIP 4'-hydroxy-PhIP Oxidation - Hydroxylation PhIP [1]
MR012942 PhIP PhIP-M1 Unclear PhIP glucuronide [2]
References
1 Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2
2 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.

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