Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012698)
Formula
SVG example
Hydroxylation
Reactant PhIP Product 4'-hydroxy-PhIP
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012704 PhIP PhIP N2-glucuronide metabolite Conjugation - Glucuronidation PhIP [1]
MR012942 PhIP PhIP-M1 Unclear PhIP glucuronide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012699 4'-hydroxy-PhIP 4'-Hydroxy-PhIP-O-Sulfate metabolite Conjugation - Sulfation PhIP [1]
MR012700 N2-hydroxy-PhIP N2-acetoxy-PhIP Conjugation - Acetylation PhIP [1]
MR012702 N2-hydroxy-PhIP N2-hydroxy-PhIP-N2-glucuronide metabolite Conjugation - Glucuronidation PhIP [1]
MR012703 N2-hydroxy-PhIP N2-hydroxy-PhIP-N3-glucuronide metabolite Conjugation - Glucuronidation PhIP [1]
MR012701 N2-hydroxy-PhIP N2-sulfonyloxy-PhIP Conjugation - Sulfation PhIP [1]
References
1 Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2
2 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.

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