Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012772)
Formula
SVG example
Oxidation
Reactant Azelaic Acid Product Malonyl CoA
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012773 Azelaic Acid Acetyl CoA Oxidation - Oxidation Azelaic Acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002982 Acetoacetyl-CoA Malonyl-CoA Unclear - Unclear Acetyl-CoA [2], [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002983 Malonyl-CoA Malonyl semialdehyde Unclear - Unclear Acetyl-CoA [2], [5], [6]
MR002985 Malonyl-CoA Triacylglycero Unclear - Unclear Acetyl-CoA [2]
References
1 Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders
2 Compartmentalised acyl-CoA metabolism and roles in chromatin regulation Mol Metab. 2020 Aug;38:100941. doi: 10.1016/j.molmet.2020.01.005.
3 High throughput (13)C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux. Microb Cell Fact. 2023 Jun 29;22(1):117. doi: 10.1186/s12934-023-02123-0.
4 Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program. Cell Rep. 2023 May 30;42(5):112488. doi: 10.1016/j.celrep.2023.112488.
5 Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis. Redox Biol. 2023 Jun 16;64:102771. doi: 10.1016/j.redox.2023.102771.
6 (2)H,(13)C-Cholesterol for Dynamics and Structural Studies of Biological Membranes. ACS Omega. 2022 May 10;7(20):17151-17160. doi: 10.1021/acsomega.2c00796.

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