Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002982)
Formula
SVG example
Unclear
Reactant Acetoacetyl-CoA Product Malonyl-CoA
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002976 Acetyl-CoA Acetoacetyl-CoA Oxidation - Beta Oxidation Acetyl-CoA [1], [2]
MR006973 Acetoacetate Acetoacetyl-CoA Unclear HSDB-41 [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002977 Acetoacetyl-CoA HMG-CoA Unclear - Unclear Acetyl-CoA [4], [2]
MR006974 Acetoacetyl-CoA Acetyl coenzyme A Unclear HSDB-41 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012772 Azelaic Acid Malonyl CoA Oxidation - Oxidation Azelaic Acid [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002983 Malonyl-CoA Malonyl semialdehyde Unclear - Unclear Acetyl-CoA [4], [6], [7]
MR002985 Malonyl-CoA Triacylglycero Unclear - Unclear Acetyl-CoA [4]
References
1 U. S. FDA Label -Acetyl-CoA
2 Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders. Front Endocrinol (Lausanne). 2022 Oct 20;13:972890. doi: 10.3389/fendo.2022.972890.
3 The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14.
4 Compartmentalised acyl-CoA metabolism and roles in chromatin regulation Mol Metab. 2020 Aug;38:100941. doi: 10.1016/j.molmet.2020.01.005.
5 Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders
6 Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis. Redox Biol. 2023 Jun 16;64:102771. doi: 10.1016/j.redox.2023.102771.
7 (2)H,(13)C-Cholesterol for Dynamics and Structural Studies of Biological Membranes. ACS Omega. 2022 May 10;7(20):17151-17160. doi: 10.1021/acsomega.2c00796.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.