Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012781)
Formula Reactant MP-513 Product MP-513 Metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012777 MP-513 MP-513 Metabolite M1 Oxidation - Thiazolidine-1-oxidation MP-513 [1], [2]
MR012780 MP-513 MP-513 Metabolite M4 Oxidation - Oxidationn MP-513 [1]
MR012779 MP-513 MP-513 Metabolite M5 Oxidation - Hydrolyzationn MP-513 [1]
References
1 Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans
2 Development of a liquid chromatography/tandem-mass spectrometry assay for the simultaneous determination of teneligliptin and its active metabolite teneligliptin sulfoxide in human plasma

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