Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012797)
Formula Reactant UK-453,061 Metabolite M21 Product UK-453,061 Metabolite M16
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012796 UK-453,061 UK-453,061 Metabolite M21 Unclear UK-453,061 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012799 UK-453,061 Metabolite M21 UK-453,061 Metabolite M2 Multi-steps Reaction - Glucuronidation; N-dealkylation; mono-oxidation UK-453,061 [1]
MR012798 UK-453,061 Metabolite M21 UK-453,061 Metabolite M22 Unclear UK-453,061 [1]
MR012800 UK-453,061 Metabolite M21 UK-453,061 Metabolite M9 Multi-steps Reaction - N-dealkylation; glucuronidation UK-453,061 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012795 UK-453,061 Metabolite M13 UK-453,061 Metabolite M16 Unclear UK-453,061 [1]
References
1 Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. Drug Metab Dispos. 2010 May;38(5):789-800.

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