Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012959)
Formula Reactant PCI-45752 (M34) Product Ibrutinib Metabolite M17
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012958 Ibrutinib PCI-45752 (M34) Unclear Ibrutinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012960 PCI-45752 (M34) Ibrutinib Metabolite M24 Multi-steps Reaction - Epoxidation; hydrolyzation Ibrutinib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012955 PCI-45773 (M35) Ibrutinib Metabolite M17 Reduction - Reduction Ibrutinib [2]
References
1 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
2 DrugBank(Pharmacology-Metabolism):Ibrutinib

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.