Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012960)
Formula	Reactant	PCI-45752 (M34)	Product	Ibrutinib Metabolite M24
Formula	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Multi-steps Reaction - Epoxidation; hydrolyzation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012958	Ibrutinib	PCI-45752 (M34)	Unclear	Ibrutinib	[1]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012959	PCI-45752 (M34)	Ibrutinib Metabolite M17	Oxidation - Hydrolyzationn	Ibrutinib	[2]

References
1	Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
2	DrugBank(Pharmacology-Metabolism):Ibrutinib

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