Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013063)
Formula Reactant 5-OH-rofecoxib Product 5-OH-rofecoxib O-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013062 Rofecoxib 5-OH-rofecoxib Other reaction - Hydoxylation Rofecoxib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013070 5-Hydroxyrofecoxib 5-Hydroxyrofecoxib-O-bate-D-glucuronide Conjugation - Glucuronidation Rofecoxib [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects

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