Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013062)
Formula
CYP3A4 ...
SVG example
Hydoxylation
Reactant Rofecoxib Product 5-OH-rofecoxib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Other reaction - Hydoxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013071 Rofecoxib 4'-Hydroxyrofecoxib-O-bate-D-glucuronide Conjugation - Glucuronidation Rofecoxib [1]
MR013064 Rofecoxib Dihydro-5-OH-rofecoxib Unclear - Unclear Rofecoxib [2]
MR013066 Rofecoxib Rofecoxib-erythro-3,4-dihydrohydroxy acid Reduction - Reduction Rofecoxib [2]
MR013068 Rofecoxib Rofecoxib-threo-3,4-dihydrohydroxy acid Unclear - Unclear Rofecoxib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013070 5-Hydroxyrofecoxib 5-Hydroxyrofecoxib-O-bate-D-glucuronide Conjugation - Glucuronidation Rofecoxib [1]
MR013063 5-OH-rofecoxib 5-OH-rofecoxib O-glucuronide Conjugation - Glucuronidation Rofecoxib [2], [3]
References
1 The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.