Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013249)
Formula	Glucuronidation
	Reactant	UK-215,364	Product	Voriconazole O-glucuronide derivative (2)
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR010837	Efinaconazole	Efinaconazole H3	Unclear - Unclear	Efinaconazole	[1]
MR013247	UK-51,060	UK-215,364	Unclear	Voriconazole	[2], [3]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013248	UK-215,364	Voriconazole O-glucuronide derivative (1)	Conjugation - Glucuronidation	Voriconazole	[2], [3]

References
1	Safety and pharmacokinetics of efinaconazole 10% solution in healthy volunteers and patients with severe onychomycosis
2	The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human
3	Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. Biochem Pharmacol. 2007 Jun 15;73(12):2020-6.

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