Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013267)
Formula
CYP1A2 ...
SVG example
8-hydroxylation
Reactant Warfarin sodium Product R-8-Hydroxywarfarin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 8-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013269 Warfarin sodium (R)9-hydroxywarfarin Oxidation - 9-hydroxylation Warfarin sodium [1], [2]
MR013270 Warfarin sodium (S)9-hydroxywarfarin Oxidation - 9-hydroxylation Warfarin sodium [1], [2]
MR013253 Warfarin sodium R-10(R)-Hydroxywarfarin Oxidation - 10-hydroxylation Warfarin sodium [1], [2]
MR013256 Warfarin sodium R-10(S)-Hydroxywarfarin Oxidation - 10-hydroxylation Warfarin sodium [1], [2]
MR013261 Warfarin sodium R-4'-Hydroxywarfarin Oxidation - 4'-hydroxylation Warfarin sodium [1], [2]
MR013263 Warfarin sodium R-6-Hydroxywarfarin Oxidation - 6-hydroxylation Warfarin sodium [1], [2]
MR013258 Warfarin sodium R-7-Hydroxywarfarin Oxidation - 7-hydroxylation Warfarin sodium [1], [2]
MR013271 Warfarin sodium R-Warfarin-R-Alcohol Reduction - Reduction Warfarin sodium [1], [2]
MR013272 Warfarin sodium R-Warfarin-S-Alcohol Reduction - Reduction Warfarin sodium [1], [2]
MR013266 Warfarin sodium S-4'-Hydroxywarfarin Oxidation - 4'-hydroxylation Warfarin sodium [1], [2]
MR013265 Warfarin sodium S-6-Hydroxywarfarin Oxidation - 6-hydroxylation Warfarin sodium [1], [2]
MR013268 Warfarin sodium S-7-Hydroxywarfarin Oxidation - 7-hydroxylation Warfarin sodium [1], [2]
MR013273 Warfarin sodium S-Warfarin-R-Alcohol Reduction - Reduction Warfarin sodium [1], [2]
MR013274 Warfarin sodium S-Warfarin-S-Alcohol Reduction - Reduction Warfarin sodium [1], [2]
References
1 Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet. 2005;44(12):1227-46.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development Curr Med Chem. 2009;16(27):3480-675. doi: 10.2174/092986709789057635.

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