Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013342)
Formula Reactant KRM-1648 Product 32-hydroxy-benzoxazinorifamycin.
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - 32-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013338 KRM-1648 25-deacetyl-benzoxazinorifamycin Oxidation - 25-deacetylation KRM-1648 [1], [2]
MR013340 KRM-1648 30-hydroxy-benzoxazinorifamycin Oxidation - Oxidationn KRM-1648 [2]
References
1 Pharmacokinetics of KRM-1648, a new benzoxazinorifamycin, in rats and dogs
2 Identification and antimicrobial activity of urinary metabolites of a rifamycin derivative in dog

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