Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013610)
Formula	CYP3A4
	Reactant	NITD609	Product	NITD609 Metabolite M37
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)				DME Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013623	NITD609	NITD609 Metabolite M20.8	Unclear	NITD609	[1]
MR013622	NITD609	NITD609 Metabolite M23.5B	Unclear	NITD609	[1]
MR013624	NITD609	NITD609 Metabolite M29.8/M34	Unclear	NITD609	[1]
MR013617	NITD609	NITD609 Metabolite M40	Unclear	NITD609	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013612	NITD609 Metabolite M37	NITD609 Metabolite M14,M24,M32	Unclear	NITD609	[1]
MR013611	NITD609 Metabolite M37	NITD609 Metabolite M18	Unclear	NITD609	[1]

References
1	KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects

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