Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013618)
Formula Reactant NITD609 Metabolite M40 Product NITD609 Metabolite M48
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013617 NITD609 NITD609 Metabolite M40 Unclear NITD609 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013619 NITD609 Metabolite M40 NITD609 Metabolite M14,M24,M32 Unclear NITD609 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013621 NITD609 Metabolite M48 NITD609 Metabolite M35 Unclear NITD609 [1]
MR013620 NITD609 Metabolite M48 NITD609 Metabolite M35.8 Unclear NITD609 [1]
References
1 KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects

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