Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013663)
Formula Reactant Sofosbuvir Product GS-56650
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Cathepsin A (CTSA) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013666 Sofosbuvir MetX Unclear Sofosbuvir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013664 GS-56650 GS-606965 Unclear Sofosbuvir [2], [3]
References
1 Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir
2 Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects
3 Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.

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