Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013666)
Formula
CES1 ...
SVG example
Reactant Sofosbuvir Product MetX
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Catalase (CAT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013663 Sofosbuvir GS-56650 Unclear Sofosbuvir [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013667 MetX GS-331007-MP Unclear Sofosbuvir [3]
References
1 Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects
2 Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.
3 Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

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