Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013758)
Formula
UGT1A3 ...
SVG example
Reactant Norbuprenorphine Product Norbuprenorphine metabolite M1
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000486 Norbuprenorphine Hydroxynorbuprenorphine Oxidation - Oxidation Buprenorphine hydrochloride [1], [2], [3]
MR000487 Norbuprenorphine Norbuprenorphine glucuronide Conjugation - Glucuronidation Buprenorphine hydrochloride [1], [2], [3]
References
1 In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005 May;33(5):689-95.
2 Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome. Drug Alcohol Depend. 2023 Jun 21;249:110832. doi: 10.1016/j.drugalcdep.2023.110832.
3 Determination of buprenorphine, norbuprenorphine, naloxone, and their glucuronides in urine by liquid chromatography-tandem mass spectrometry. Drug Test Anal. 2021 Sep;13(9):1658-1667. doi: 10.1002/dta.3104.

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