Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000486)
Formula Reactant Norbuprenorphine Product Hydroxynorbuprenorphine
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013758 Norbuprenorphine Norbuprenorphine metabolite M1 Unclear Norbuprenorphine [1]
MR000487 Norbuprenorphine Norbuprenorphine glucuronide Conjugation - Glucuronidation Buprenorphine hydrochloride [2], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000489 Hydroxybuprenorphine Hydroxynorbuprenorphine Oxidation - N-Dealkylation Buprenorphine hydrochloride [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000488 Hydroxynorbuprenorphine Hydroxynorbuprenorphine glucuronide Conjugation - Glucuronidation Buprenorphine hydrochloride [2]
References
1 Contribution of the different UDP-glucuronosyltransferase (UGT) isoforms to buprenorphine and norbuprenorphine metabolism and relationship with the main UGT polymorphisms in a bank of human liver microsomes. Drug Metab Dispos. 2010 Jan;38(1):40-5.
2 In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005 May;33(5):689-95.
3 Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome. Drug Alcohol Depend. 2023 Jun 21;249:110832. doi: 10.1016/j.drugalcdep.2023.110832.
4 Determination of buprenorphine, norbuprenorphine, naloxone, and their glucuronides in urine by liquid chromatography-tandem mass spectrometry. Drug Test Anal. 2021 Sep;13(9):1658-1667. doi: 10.1002/dta.3104.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.