Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013783)
Formula
SVG example
Glucuronidation
Reactant Demethyleneberberine Product Demethyleneberberine-2,3-di-O-beta-D-glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013779 Berberine Demethyleneberberine Oxidation - Demethylenation Berberine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013780 Demethyleneberberine 2,3,10-trihydroxyberberine Oxidation - Demethylation Berberine [1], [2]
MR013782 Demethyleneberberine 2,3,9-trihydroxyberberine Unclear - Unclear Berberine [1]
MR013781 Demethyleneberberine Demethyleneberberine-2-O-sulfate Conjugation - Sulfation Berberine [1]
References
1 The metabolism of berberine and its contribution to the pharmacological effects
2 CYP2D plays a major role in berberine metabolism in liver of mice and humans

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