Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013780)
Formula
CYP2D6 ...
SVG example
Demethylation
Reactant Demethyleneberberine Product 2,3,10-trihydroxyberberine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013779 Berberine Demethyleneberberine Oxidation - Demethylenation Berberine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013782 Demethyleneberberine 2,3,9-trihydroxyberberine Unclear - Unclear Berberine [1]
MR013783 Demethyleneberberine Demethyleneberberine-2,3-di-O-beta-D-glucuronide Conjugation - Glucuronidation Berberine [1]
MR013781 Demethyleneberberine Demethyleneberberine-2-O-sulfate Conjugation - Sulfation Berberine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013776 3,10-demethylpalmatine 2,3,10-trihydroxyberberine Oxidation - Demethylation Berberine [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013777 2,3,10-trihydroxyberberine 2,3,10-trihydroxyberberine-2-O-sulfate Conjugation - Sulfation Berberine [1]
References
1 The metabolism of berberine and its contribution to the pharmacological effects
2 CYP2D plays a major role in berberine metabolism in liver of mice and humans

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