Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013792)
Formula
SVG example
Reduction
Reactant Berberine Product Columbamine
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013795 Berberine 3,9-demethylpalmatine Unclear - Unclear Berberine [1]
MR013787 Berberine Berberrubine Oxidation - Demethylation Berberine [1], [2], [3]
MR013779 Berberine Demethyleneberberine Oxidation - Demethylenation Berberine [1], [2]
MR013796 Berberine Dihydroberberine Reduction - Reduction Berberine [1]
MR013774 Berberine Jatrorrhizine Reduction - Reduction Berberine [1]
MR013789 Berberine Thalfendine Oxidation - Demethylation Berberine [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013793 Columbamine Columbamin-2-O-beta-D-glucuronide Unclear - Unclear Berberine [1]
MR013794 Columbamine Palmatine Oxidation - Methylation Berberine [1]
References
1 The metabolism of berberine and its contribution to the pharmacological effects
2 CYP2D plays a major role in berberine metabolism in liver of mice and humans
3 Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

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