Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013774)
Formula Reactant Berberine Product Jatrorrhizine
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013795 Berberine 3,9-demethylpalmatine Unclear - Unclear Berberine [1]
MR013787 Berberine Berberrubine Oxidation - Demethylation Berberine [1], [2], [3]
MR013792 Berberine Columbamine Reduction - Reduction Berberine [1]
MR013779 Berberine Demethyleneberberine Oxidation - Demethylenation Berberine [1], [2]
MR013796 Berberine Dihydroberberine Reduction - Reduction Berberine [1]
MR013789 Berberine Thalfendine Oxidation - Demethylation Berberine [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013775 Jatrorrhizine 3,10-demethylpalmatine Oxidation - Demethylation Berberine [1]
MR013784 Jatrorrhizine Jatrorrhizine-3-O-beta-D-glucuronide Conjugation - Glucuronidation Berberine [1]
MR013785 Jatrorrhizine Jatrorrhizine-3-O-sulfate Conjugation - Sulfation Berberine [1]
MR013786 Jatrorrhizine Palmatine Oxidation - Methylation Berberine [1]
References
1 The metabolism of berberine and its contribution to the pharmacological effects
2 CYP2D plays a major role in berberine metabolism in liver of mice and humans
3 Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

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