Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR014146)
Formula
SVG example
Oxidation; C-demethylation
Reactant Ombitasvir Metabolite M26 Product Ombitasvir Metabolite M36
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Multi-steps Reaction - Oxidation; C-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014143 Ombitasvir Metabolite M23 Ombitasvir Metabolite M26 Oxidation - Oxidation Ombitasvir [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014144 Ombitasvir Metabolite M26 Ombitasvir Metabolite M25 Oxidation - Oxidation Ombitasvir [1]
MR014150 Ombitasvir Metabolite M26 Ombitasvir Metabolite M28 Multi-steps Reaction - Oxidation; C-demethylation Ombitasvir [1]
MR014147 Ombitasvir Metabolite M26 Ombitasvir Metabolite M29 Multi-steps Reaction - Oxidation; C-demethylation Ombitasvir [1]
MR014149 Ombitasvir Metabolite M26 Ombitasvir Metabolite M34 Multi-steps Reaction - Oxidation; C-demethylation Ombitasvir [1]
MR014148 Ombitasvir Metabolite M26 Ombitasvir Metabolite M35 Multi-steps Reaction - Oxidation; C-demethylation Ombitasvir [1]
MR014145 Ombitasvir Metabolite M26 Ombitasvir Metabolite M37 Multi-steps Reaction - Oxidation; C-demethylation Ombitasvir [1]
References
1 Metabolism and disposition of pan-genotypic inhibitor of hepatitis C virus NS5A ombitasvir in humans. Drug Metab Dispos. 2016 Aug;44(8):1148-57.

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