Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00016)
Xenobiotics Name
Clofibrate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2796
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [4]
References
1 HMG-CoA reductase and PPARalpha are involved in clofibrate-induced apoptosis in human keratinocytes. Apoptosis. 2006 Feb;11(2):265-75.
2 Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol. 2009 Sep;76(3):588-95.
3 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
4 Cisplatin-mediated cytotoxicity through inducing CYP4A 11 expression in human renal tubular epithelial cells. J Toxicol Sci. 2015 Dec;40(6):895-900.

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