Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00040)
Xenobiotics Name
Furosemide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
3440
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Carbonic anhydrase II (CA2) DME Info Homo sapiens [1]
Thiopurine methyltransferase (TPMT) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Carbonic anhydrase II (CA2) DME Info Ki = 0.065 microM [1]
References
1 Carbonic anhydrase inhibitorsComparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21.
2 Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Eur J Clin Pharmacol. 1996;49(5):393-6.
3 Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos. 2008 May;36(5):816-23.

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