Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00078)
Xenobiotics Name
Rofecoxib
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5090
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [1], [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Prostaglandin G/H synthase 1 (COX-1) DME Info IC50 = 1.7 microM [1], [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 0.001 microM [3]
References
1 2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. J Med Chem. 1999 Apr 8;42(7):1274-81.
2 3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1195-8.
3 Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor. Bioorg Med Chem Lett. 2002 Mar 11;12(5):779-82.

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