Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00111)
Xenobiotics Name
Erythromycin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
12560
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Beta-lactamase (blaB) DME Info Corynebacterium acnes [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 0.19 microM [3]
References
1 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
2 Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms. J Appl Microbiol. 2014 Mar;116(3):492-501.
3 Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. J Med Chem. 2009 Feb 26;52(4):1180-9.
4 Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicol Appl Pharmacol. 2007 Dec 1;225(2):142-53.

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