Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00164)
Xenobiotics Name
Azithromycin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=447043"></iframe>
3D MOL 2D MOL
PubChem CID
447043
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Ampc beta-lactamase (ampC) DME Info Burkholderia cenocepacia [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [3]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [3]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [4]
Beta-lactamase (blaB) DME Info Burkholderia cenocepacia [1]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 > 10 microM [2]
References
1 Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia. Res Microbiol. 2009 Mar;160(2):144-51.
2 N'-substituted-2'-O,3'-N-carbonimidoyl bridged macrolides: novel anti-inflammatory macrolides without antimicrobial activity. J Med Chem. 2012 Jul 12;55(13):6111-23.
3 The influence of azithromycin on the biofilm formation of Pseudomonas aeruginosa in vitro. Chemotherapy. 1996 May-Jun;42(3):186-91.
4 In vitro activities of antibiotics and antimicrobial cationic peptides alone and in combination against methicillin-resistant Staphylococcus aureus biofilms. Antimicrob Agents Chemother. 2012 Dec;56(12):6366-71.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.