Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00209)
Xenobiotics Name
Clozapine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
135398737
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Asparagine synthetase (ASNS) DME Info Homo sapiens [2], [3]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [5]
References
1 Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites. Chem Res Toxicol. 2011 Aug 15;24(8):1263-74.
2 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
3 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
4 Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? Pharmacogenomics J. 2005;5(5):298-304.
5 Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos. 2008 May;36(5):816-23.

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