Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00340)
Xenobiotics Name
Atorvastatin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
60823
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [3]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [4]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [5]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [6]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [7], [8]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 5.1 microM [2]
References
1 Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes. Biochem Pharmacol. 2006 Feb 28;71(5):605-14.
2 Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13.
3 The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
4 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
5 Hepatic Responses to Inhibition of 3-hydroxy-3-methylglutaryl-CoA Reductase: A Comparison of Atorvastatin and Simvastatin Biochim Biophys Acta. 1998 Jan 23;1389(3):213-21.
6 Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
7 Effect of short term treatment with simvastatin and atorvastatin on lipids and paraoxonase activity in patients with hyperlipoproteinaemia. Curr Med Res Opin. 2004 Aug;20(8):1321-7.
8 Antioxidant effect of atorvastatin is independent of PON1 gene T(-107)C, Q192R and L55M polymorphisms in hypercholesterolaemic patients. Curr Med Res Opin. 2005 May;21(5):777-84.

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