Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00359)
Xenobiotics Name
Fluvastatin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
446155
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [3]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [4]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data HMG-CoA reductase (HMGCR) DME Info IC50 = 0.000353 microM [2]
References
1 Effect of atorvastatin and fluvastatin on the metabolism of midazolam by cytochrome P450 in vitro. Anaesthesia. 2005 Aug;60(8):747-53.
2 Currently available hypolipidaemic drugs and future therapeutic developments. Baillieres Clin Endocrinol Metab. 1995 Oct;9(4):825-47.
3 Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. FEBS J. 2014 Aug;281(16):3719-38.
4 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.

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