Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00361)
Xenobiotics Name
Gemcitabine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
60750
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [1]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Myeloperoxidase (MPO) DME Info Homo sapiens [3]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [2]
References
1 Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. Mol Ther. 2011 Jan;19(1):188-95.
2 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
3 Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.

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