Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00372)
Xenobiotics Name
Panobinostat
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
6918837
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Adenosine aminohydrolase (ADA) DME Info Homo sapiens [1]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [4]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [5], [6]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [7]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [6]
Sulfotransferase 1A2 (SULT1A2) DME Info Homo sapiens [8]
References
1 Effects of obstructive sleep apnea style intermittent hypoxia on endothelin-1, nitric oxide, and nitric oxide synthase in endothelium: experiment with human umbilical vein endothelial cells. Zhonghua Yi Xue Za Zhi. 2007 Aug 21;87(31):2189-92.
2 Negative regulation of NEP expression by hypoxia. Prostate. 2013 May;73(7):706-14.
3 Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. Eur J Cancer. 2009 Nov;45(16):2882-92.
4 Molecular basis of 'hypoxic' breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling. Radiat Oncol. 2013 Mar 4;8:46.
5 Development of long noncoding RNA-based strategies to modulate tissue vascularization. J Am Coll Cardiol. 2015 Nov 3;66(18):2005-2015.
6 Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels. PLoS One. 2013 Nov 13;8(11):e78847.
7 Intravenous oxygen therapy increases the activity of the antioxidative and antiatherogenic serum enzyme paraoxonase 1. Forsch Komplementarmed Klass Naturheilkd. 2005 Dec;12(6):342-6.
8 Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. PLoS One. 2013;8(2):e55146.

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