Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00519)
Xenobiotics Name
Nimesulide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug Marketed but Withdrawn from Market
Structure
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3D MOL 2D MOL
PubChem CID
4495
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [2], [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aromatase (CYP19A1) DME Info IC50 = 27 microM [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 0.015 microM [4]
References
1 Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells. J Med Chem. 2007 Apr 5;50(7):1635-44.
2 Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
3 Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):131-49.
4 Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry. Bioorg Med Chem Lett. 1998 Mar 3;8(5):529-34.
5 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.

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