Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00587)
Xenobiotics Name
Trichloroethylene
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
6575
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [2]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [1], [3]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [4]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [3]
References
1 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
2 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
3 Kinase-dependent, retinoic acid receptor-independent up-regulation of cyclooxygenase-2 by all-trans retinoic acid in human mesangial cells. Br J Pharmacol. 2006 Sep;149(2):215-25.
4 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.

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