Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00601)
Xenobiotics Name
Butylated hydroxytoluene
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
31404
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Carbonic anhydrase II (CA2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Carbonic anhydrase II (CA2) DME Info Ki = 0.63 microM [1]
References
1 Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols bioorg. Med Chem. 2009 Apr 15;17(8):3207-11.
2 Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Xenobiotica. 2008 Jun;38(6):574-86.
3 Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes. Drug Metab Dispos. 2013 Dec;41(12):2087-94.

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