Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00606)
Xenobiotics Name
Colforsin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
47936
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [2]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [3], [2]
Sulfotransferase 2B1 (SULT2B1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [1]
Steroid 11-beta-hydroxylase (CYP11B1) DME Info Homo sapiens [4]
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [5]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [1]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [6]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [7], [6]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [8]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [7], [2]
Peroxisomal multifunctional enzyme 2 (HSD17B4) DME Info Homo sapiens [7], [2]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [9]
References
1 Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
2 Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish. Aquat Toxicol. 2012 Jun 15;114-115:173-81.
3 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
4 Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression. J Endocrinol. 2003 Jan;176(1):69-82.
5 The effect of valproate and levetiracetam on steroidogenesis in forskolin-stimulated H295R cells. Epilepsia. 2010 Nov;51(11):2280-8.
6 Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells. Oncogene. 2006 Nov 23;25(55):7311-23.
7 The H295R system for evaluation of endocrine-disrupting effects. Ecotoxicol Environ Saf. 2006 Nov;65(3):293-305.
8 cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11beta-HSD2 expression. Toxicol Appl Pharmacol. 2018 Aug 1;352:77-86.
9 Treatment of human T cells with bisperoxovanadium phosphotyrosyl phosphatase inhibitors leads to activation of cyclooxygenase-2 gene. J Biol Chem. 2003 Feb 28;278(9):6992-7000.

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