Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00623)
Xenobiotics Name
SC-58125
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
115239
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Prostaglandin G/H synthase 1 (COX-1) DME Info IC50 = 32 microM [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 0.05 microM [3]
References
1 Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer. J Steroid Biochem Mol Biol. 2005 May;95(1-5):129-36.
2 Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitorsUtilisation of a biotransformation approach. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4509-14.
3 1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. J Med Chem. 1995 Oct 27;38(22):4570-8.

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