Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00634)
Xenobiotics Name
Hydroxytamoxifen
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
449459
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Metallothionein-1A (MT1A) DME Info Homo sapiens [2]
Metallothionein-2A (MT2A) DME Info Homo sapiens [2]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [3]
References
1 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
2 Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. EMBO J. 2009 Mar 4;28(5):523-32.
3 Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res. 2006 Jul 15;66(14):7334-40.

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