Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00659)
Xenobiotics Name
Exisulind
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
5472495
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [2]
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [3], [4]
DME(s) Induced by This Xenobiotics
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [5]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [6], [7]
References
1 In vitro evaluation of oxidative damage from organic solvent vapours on human skin. Toxicol In Vitro. 2006 Apr;20(3):324-31.
2 Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem. 2011 Mar 24;54(6):1896-902.
3 Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):326-32.
4 CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells. Int J Oncol. 2008 May;32(5):1105-10.
5 CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab Dispos. 2002 Jul;30(7):795-804.
6 Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). Drug Metab Dispos. 2008 Dec;36(12):2556-63.
7 Low level occupational exposure to styrene: its effects on DNA damage and DNA repair. Int J Hyg Environ Health. 2011 Mar;214(2):127-37.

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