Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00664)
Xenobiotics Name
CI-1040
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
6918454
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [1]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [1]
References
1 U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol. 2014 Dec;88(12):2243-59.

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