Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00701)
Xenobiotics Name
Beta-carboline
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
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3D MOL 2D MOL
PubChem CID
64961
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [1]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Monoamine oxidase type B (MAO-B) DME Info Ki = 1.2 microM [2]
References
1 Nicotine-mediated suppression of the retinoic acid metabolizing enzyme CYP26A1 limits the oncogenic potential of breast cancer. Cancer Sci. 2011 Jun;102(6):1158-63.
2 Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO. Bioorg Med Chem. 2011 Dec 15;19(24):7416-24.
3 Regulation of dioxin receptor function by different beta-carboline alkaloids. Arch Toxicol. 2010 Aug;84(8):619-29.

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