Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00829)
Xenobiotics Name
Niflumic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
4488
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2], [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info IC50 = 13 microM [1]
References
1 Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos. 2011 Feb;39(2):322-9.
2 Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
3 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.

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