Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00869)
Xenobiotics Name
4-hydroxy-2-nonenal
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
5283344
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [1]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [2]
Catechol O-methyltransferase (COMT) DME Info Homo sapiens [3]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [4]
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [3]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [5]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [6]
Succinic semialdehyde reductase (AKR7A2) DME Info Homo sapiens [6], [7]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [2]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [8]
References
1 Differences in susceptibility to inactivation of human aldehyde dehydrogenases by lipid peroxidation byproducts. Chem Res Toxicol. 2012 Mar 19;25(3):722-9.
2 Catabolism of 4-hydroxy-2-trans-nonenal by THP1 monocytes/macrophages and inactivation of carboxylesterases by this lipid electrophile. Chem Biol Interact. 2011 Oct 15;194(1):1-12.
3 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
4 Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1. Chem Biol Interact. 1997 Dec 12;108(1-2):67-78.
5 Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. J Lipid Res. 2004 Dec;45(12):2211-20.
6 Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. Neurotoxicology. 2012 Oct;33(5):1368-74.
7 Protective effect of inducible aldo-keto reductases on 4-hydroxynonenal- induced hepatotoxicity. Chem Biol Interact. 2019 May 1;304:124-130.
8 Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1. Chem Biol Interact. 2018 Jan 5;279:10-20.

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