Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01116)
Xenobiotics Name
25-hydroxycholesterol
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Health Hazard/Toxicant
Structure
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3D MOL 2D MOL
PubChem CID
65094
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [2]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data HMG-CoA reductase (HMGCR) DME Info IC50 = 0.3 microM [2]
References
1 Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. Eur J Pharmacol. 2007 Oct 1;571(2-3):97-105.
2 Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription. J Med Chem. 1994 Jul 22;37(15):2343-51.
3 LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. Atherosclerosis. 2009 Nov;207(1):38-44.
4 Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. Exp Mol Med. 2002 May 31;34(2):137-44.

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