Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01468)
Xenobiotics Name
SC-560
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4306515"></iframe>
3D MOL 2D MOL
PubChem CID
4306515
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Prostaglandin G/H synthase 1 (COX-1) DME Info IC50 = 0.007 microM [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 6.3 microM [3]
References
1 Geraniol protects against the protein and oxidative stress induced by rotenone in an in Vitro model of Parkinson's disease. Neurochem Res. 2018 Oct;43(10):1947-1962.
2 Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem. 1997 Apr 25;40(9):1347-65.
3 Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. J Med Chem. 2012 Mar 8;55(5):2287-300.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.