Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01514)
Xenobiotics Name
Deoxynivalenol
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Mycotoxin
Structure
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3D MOL 2D MOL
PubChem CID
40024
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [3]
Steroid 11-beta-hydroxylase (CYP11B1) DME Info Homo sapiens [1]
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [1]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [1]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [4]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
References
1 An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. Toxicol Lett. 2012 Nov 15;214(3):268-78.
2 Transcriptomic profile indicative of immunotoxic exposure: in vitro studies in peripheral blood mononuclear cells. Toxicol Sci. 2010 Nov;118(1):19-30.
3 Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expression. Free Radic Biol Med. 2010 Jul 1;49(1):50-60.
4 The food-associated ribotoxin deoxynivalenol modulates inducible NO synthase in human intestinal cell model. Toxicol Sci. 2015 Jun;145(2):372-82.

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